The way that you should handle the missions is to do all of the side missions first before completing the story missions (marked Priority).
One thing to be aware of is that progressing through the story missions will lock out the side missions. If you reach Cerberus HQ with an overall readiness of 6000, but your Galaxy at War percentage is still at 50%, then your effective military readiness will be 50% of that, or 3000. Basically, whatever your galactic readiness rating is, then your effective military readiness will be that percentage of the your overall readiness. The way that your effective military readiness is calculated is by taking your overall readiness and multiplying it by your galactic readiness rating (Galaxy at War percentage) (OMR * GRR% = EMR).
What you want is that by the time you launch the assault on Cerberus headquarters, your effective military readiness (the green bar) is at or above 4000. You will have to complete every side mission, carry over specific choices from ME2 (saving the Collector Base, for instance), and make specific storyline choices (deceiving the krogan and making peace between the quarians and geth).
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